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Interaction of propranolol with GABA stimulated diazepam binding to rat brain membranes
C Benistant1, C Rey, P Fonlupt
1Unité INSERM 205 Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées, Villeurbanne, France.
General Pharmacology
|January 1, 1988
Abstract:
1. In the case of an intraperitoneal propranolol injection to rats (25 mg/kg), there was no modification in benzodiazepine and gamma-amino-butyric acid recognition sites since [3H]diazepam or [3H]-muscimol binding was not affected. 2. There was an increase in GABA stimulated-diazepam binding (100%, statistical risk lower than 1%). 3. This last result suggests that propranolol treatment can stimulate GABA-benzodiazepine receptor coupling.