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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Nov 2, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia
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Topiramate-induced Acute Transient Myopia and Angle Narrowing.

Summaya Khan1, Ammarah Ashraf1, Hassaan Javaid1

  • 1Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|June 9, 2021
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Summary
This summary is machine-generated.

Sulphamate medications like topiramate can cause rare ocular side effects, including angle closure glaucoma and myopia. Prompt discontinuation of topiramate led to full recovery in all reported cases.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Sulphamate drugs are commonly prescribed for systemic conditions.
  • Ocular adverse effects from these medications are rare but documented.
  • Early diagnosis relies heavily on patient medical and drug history.

Observation:

  • This study details three cases of ocular side effects attributed to topiramate use.
  • One case presented with narrow angles and normal intra-ocular pressure (IOP).
  • Another case showed no macular striae, an atypical presentation.

Findings:

  • Topiramate can induce angle closure glaucoma and myopia.
  • Ocular side effects typically manifest within weeks of treatment initiation.
  • Immediate cessation of topiramate is crucial for recovery.

Implications:

  • Ophthalmologists should consider topiramate as a potential cause of acute angle closure glaucoma.
  • Awareness of these ocular risks is vital for clinicians prescribing sulphamate drugs.
  • Prompt diagnosis and management can prevent permanent vision loss.