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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal MicroRNA: Diagnostic Marker and Therapeutic Tool for Lung Diseases

Yu Hua1, Yan Ding1, Yapeng Hou1

  • 1Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, China.

Current Pharmaceutical Design
|June 9, 2021
PubMed

Insights

Exosomes and their microRNA cargo are crucial in lung health and disease, offering potential for new diagnostic and therapeutic strategies for various pulmonary disorders.

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Biochemistry

Background:

  • Lung diseases pose significant health risks globally.
  • Exosomes mediate intercellular communication, impacting lung homeostasis.
  • Exosomes contain microRNAs, critical in cellular signaling.

Purpose of the Study:

  • To review the role of exosomes and exosomal microRNAs in lung disease pathogenesis.
  • To explore the diagnostic and prognostic potential of exosomes in pulmonary disorders.
  • To discuss exosome-based therapeutic strategies for lung diseases.

Main Methods:

  • Literature review of recent findings on exosomes in lung diseases.
  • Analysis of exosome involvement in intercellular communication within the lungs.
  • Synthesis of data on exosomal microRNAs in lung disease progression.

Main Results:

  • Exosomes are implicated in the pathogenesis of COPD, asthma, fibrosis, ALI, lung cancer, ILD, and TB.
  • Exosomal microRNAs serve as potential biomarkers for lung disease diagnosis and prognosis.
  • Exosomes are involved in maintaining lung tissue and airway structure homeostasis.

Conclusions:

  • Exosomes and exosomal microRNAs are key players in lung disease.
  • Targeting exosomes offers promising avenues for novel diagnostic and therapeutic interventions.
  • Further research into exosome biology can advance lung disease management.
Keywords:
Lung diseasesbiomarkersbronchoalveolar lavage fluid.exosomesintercellular communicationmicroRNAstherapeutics

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