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Post-immunotherapy imaging in lung cancer.

G S Shroff¹, C D Strange¹, M Altan²

¹The University of Texas MD Anderson Cancer Center, Thoracic Imaging, 1515 Holcombe Blvd. Unit 1478, Houston, TX 77030, USA.

Clinical Radiology

|June 9, 2021

Summary

This summary is machine-generated.

Immunotherapy using immune checkpoint inhibitors (ICIs) revolutionizes cancer care, especially for metastatic non-small cell lung cancer (NSCLC). This review covers ICI therapy, unique response patterns, and immune-related adverse events in NSCLC.

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Area of Science:

Oncology
Immunology
Radiology

Background:

Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has transformed cancer treatment.
ICIs activate the immune system to combat various cancers, including metastatic non-small cell lung cancer (NSCLC).
Unique response patterns and immune-related adverse events (irAEs) are characteristic of ICI therapy.

Purpose of the Study:

To review the role of immunotherapy in cancer management.
To focus on ICIs in NSCLC treatment.
To discuss radiological response criteria and imaging findings of irAEs associated with immunotherapy.

Main Methods:

Literature review of immunotherapy in cancer treatment.
Focus on immune checkpoint inhibitors (ICIs) for non-small cell lung cancer (NSCLC).
Analysis of radiological response criteria and imaging spectrum of immune-related adverse events.

Main Results:

ICIs have significantly altered cancer management, offering new therapeutic avenues.
Specialized response criteria are needed to accurately assess treatment efficacy with ICIs.
A spectrum of immune-related adverse events can manifest on imaging.

Conclusions:

Immunotherapy with ICIs is a cornerstone in treating advanced cancers like NSCLC.
Radiological assessment requires adapted criteria to interpret ICI treatment responses.
Understanding the imaging features of irAEs is crucial for patient management.