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Metabolomics and cancer preventive behaviors in the BC Generations Project
J Qi1, J J Spinelli1, T J B Dummer1
1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Scientific Reports
|June 9, 2021
Summary
Metabolomics reveals how lifestyle choices like diet and exercise impact cancer prevention. Key behaviors such as maintaining a healthy body mass index (BMI) and consuming fruits and vegetables significantly alter metabolic profiles.
Area of Science:
- Metabolomics
- Cancer Prevention
- Lifestyle Medicine
Background:
- Metabolomics offers insights into metabolic shifts driven by lifestyle behaviors.
- These shifts may be relevant to understanding carcinogenesis.
- Cancer preventive behaviors can influence metabolic profiles.
Purpose of the Study:
- To examine associations between metabolic measures and cancer preventive behaviors.
- To identify specific metabolic alterations linked to lifestyle choices.
- To understand the metabolic impact of behaviors relevant to cancer prevention.
Main Methods:
- Utilized non-targeted nuclear magnetic resonance (NMR) metabolomics.
- Analyzed data from 1319 participants in the BC Generations Project.
- Employed linear regression with a false discovery rate (FDR) of 0.10.
Main Results:
- Significant associations found between 173 metabolites and BMI, 103 with fruit/vegetable intake, 71 with alcohol consumption, and 6 with physical activity.
- Glycoprotein acetyls (inflammation marker) negatively associated with BMI and fruit/vegetable intake.
- Polyunsaturated fatty acids positively associated with fruit/vegetable intake; HDL subclasses associated with lower BMI.
Conclusions:
- Lifestyle behaviors, particularly those related to BMI, diet, and alcohol, have a substantial impact on metabolic profiles.
- Metabolomic analysis provides valuable insights into the biological pathways underlying cancer prevention.
- Findings highlight the interconnectedness of lifestyle, metabolism, and cancer risk.
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