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Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

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Updated: Nov 2, 2025

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Controlled biointerfaces with biomimetic phosphorus-containing polymers.

Suphatra Hiranphinyophat¹, Yasuhiko Iwasaki²

¹Graduate School of Science and Engineering, Kansai University, Suita, Japan.

Science and Technology of Advanced Materials

|June 9, 2021

Summary

This summary is machine-generated.

Biomimetic phosphorus-containing polymers improve medical device performance by enhancing biocompatibility and adding new functions. These advanced materials offer unique biointerfacial properties, overcoming limitations of current medical technologies.

Keywords:

212 Surface and interfaces 30 Bio-inspired and biomedical materials Phosphorus-containing polymer bone targeting emulsion mineralization nonfouling polyphosphoester surface modification zwitterionic polymer

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biocompatibility Engineering

Background:

Phosphorus is vital in biological molecules like DNA, cell membranes, and bone.
Phosphorus-inspired materials exhibit beneficial biointerfacial properties such as nonfouling and blood compatibility.
Current materials often cause adverse host responses, limiting medical device longevity.

Purpose of the Study:

To review recent advancements in controlling biointerfacial phenomena using phosphorus-containing polymers.
To highlight the potential of biomimetic polymers in improving medical device reliability and function.
To focus on zwitterionic phosphorylcholine polymers and polyphosphoesters.

Main Methods:

Literature review of phosphorus-containing polymers and their biointerfacial applications.
Analysis of material design strategies for enhanced biocompatibility.
Discussion of specific polymer types: phosphorylcholine polymers and polyphosphoesters.

Main Results:

Phosphorus-containing polymers offer tunable properties for biomaterial design.
These polymers demonstrate improved nonfouling, lubricity, and mineralization induction.
Biomimetic design addresses host responses, enhancing material integration.
Zwitterionic phosphorylcholine polymers and polyphosphoesters show significant promise.

Conclusions:

Biomimetic phosphorus-containing polymers are key to developing next-generation medical materials.
These polymers enhance biocompatibility and introduce novel functionalities.
Further research into phosphorylcholine polymers and polyphosphoesters will advance biomedical applications.