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Updated: Nov 2, 2025
05:03
A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
Published on: February 24, 2023
833
Calcium: More Than Bone? Implications for Clinical Practice and Theory.
Jacob M Hands1, Lawrence S Moy1
1South Bay Institute of Clinical Research, University of California, Berkeley, CA, USA.
Journal of Clinical Medicine Research
|June 9, 2021
Summary
Serum calcium levels offer valuable prognostic insights. Understanding variations in calcemic status is crucial for patient care, impacting cardiovascular health and metabolic function.
Area of Science:
- Biochemistry
- Endocrinology
- Clinical Medicine
Background:
- Serum calcium is a standard laboratory test.
- Its interpretation in normal physiologic functioning is often overlooked.
- Variations in calcemic status have significant clinical implications.
Purpose of the Study:
- To explore the implications of serum calcium levels.
- To provide guidelines for interpreting serum calcium.
- To discuss the clinical significance of high, low, and normal calcium levels.
Main Methods:
- Literature review focusing on serum calcium.
- Analysis of factors influencing calcemic status.
- Examination of prognostic indicators associated with calcium levels.
Main Results:
- Serum calcium concentration is a valuable prognostic indicator.
- Variations are linked to malignancy, PTH, vitamin D, IGF-1, DiGeorge syndrome, and CaSR mutations.
- High or low serum calcium is associated with increased risk of thromboembolic events, MACE, cardiac remodeling, hypertension, cognitive decline, and insulin resistance.
Conclusions:
- Greater attention to patient calcemic status is warranted.
- Serum calcium variations provide critical prognostic information.
- Understanding calcemic status is essential for comprehensive patient management.
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