Related Experiment Video

Updated: Nov 2, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.4K

Physio-pathological effects of m6A modification and its potential contribution to melanoma

Y Liao1, P Han1, Y Zhang2

  • 1Department of Oncology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400013, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|June 9, 2021
PubMed

Insights

N6-adenosine methylation (m6A) is a key RNA regulator implicated in cancer. This review details m6A's role in normal and melanoma cells, exploring its therapeutic potential.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • N6-adenosine methylation (m6A) is the most common internal RNA modification, particularly in messenger RNAs.
  • m6A regulates RNA processes like splicing, stability, and translation via interactions with specific proteins.
  • Dysregulation of m6A is linked to human cancers, including melanoma.

Purpose of the Study:

  • To summarize current knowledge on m6A regulation and its biological functions.
  • To emphasize the role of m6A deregulation and its regulators in melanoma.
  • To explore the therapeutic potential of targeting m6A in melanoma and other diseases.

Main Methods:

  • Review of existing literature on m6A modification.
  • Analysis of m6A regulators' roles in cellular processes.
  • Focus on m6A deregulation in the context of melanoma.

Main Results:

  • m6A modifications are dynamically regulated by writers, erasers, and readers.
  • Aberrant m6A patterns are observed in melanoma development and progression.
  • m6A regulators present potential therapeutic targets for melanoma treatment.

Conclusions:

  • m6A plays a critical role in both normal cellular functions and oncogenesis.
  • Targeting m6A pathways offers a promising avenue for novel melanoma therapies.
  • Further research into m6A is crucial for developing new treatments for cancer and other diseases.
Keywords:
MelanomaRNA modificationTumorm6A

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.6K
Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry08:45

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

2.6K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.6K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.7K
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
457