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Related Experiment Video

Updated: Nov 2, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Far-Forward Blood Donation and Donor Performance.

Collin A Guillotte, Brian K Schilling

Journal of Special Operations Medicine : a Peer Reviewed Journal for SOF Medical Professionals

|June 9, 2021

Summary

Whole blood donation temporarily reduces male physical performance, decreasing peak oxygen uptake and time to exhaustion for up to 48 hours. However, these effects are minimal and can be mitigated by exercise training.

Area of Science:

Military Medicine
Physiology
Transfusion Medicine

Background:

Fresh whole blood transfusion offers advantages in far-forward settings compared to component therapy.
The demanding nature of far-forward operations may impact donor physical performance post-donation.

Purpose of the Study:

To review the literature on the immediate effects of a standard whole blood donation (450mL) on male donor physical performance.

Main Methods:

Literature review of studies examining physiological parameters after whole blood donation.

Main Results:

Whole blood donation (450mL) can reduce peak oxygen uptake (VO2peak) by 4-15% and time to exhaustion (TTE) by 10-19% within 24-48 hours.
Limited data suggest no significant decrease in anaerobic or cognitive performance, though further research is needed.

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Last Updated: Nov 2, 2025

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

Published on: June 6, 2025

Pre-clinical Model of Cardiac Donation after Circulatory Death

Pre-clinical Model of Cardiac Donation after Circulatory Death

Published on: August 2, 2019

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Conclusions:

Post-donation physical performance decrements are minimal and temporary.
Proper exercise training may help mitigate the temporary reductions in physical performance observed after blood donation.