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Updated: Nov 2, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
07:56

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model

Published on: January 10, 2025

850

Retraction

    Journal of Cellular Physiology
    |June 9, 2021
    PubMed

    Insights

    This study on bladder cancer signaling has been retracted due to significant flaws. The carcinogenic role of K-Ras-ERK1/2 signaling and H1.2 phosphorylation is now considered invalid.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cell Signaling

    Context:

    • The article investigated the K-Ras-ERK1/2 signaling pathway in bladder cancer.
    • It focused on the inhibition of H1.2 phosphorylation at Threonine 146 (T146) as a potential carcinogenic mechanism.

    Purpose:

    • To elucidate the role of K-Ras-ERK1/2 signaling in bladder cancer development.
    • To examine the specific mechanism involving H1.2 phosphorylation at T146.

    Summary:

    • The article "Carcinogenic role of K-Ras-ERK1/2 signaling in bladder cancer via inhibition of H1.2 phosphorylation at T146" has been retracted.
    • Retraction was based on an investigation prompted by third-party allegations, revealing flaws and inconsistencies.
    • The journal editors deemed the article's conclusions invalid due to these issues.

    Impact:

    • The retraction invalidates previous findings on K-Ras-ERK1/2 signaling and H1.2 phosphorylation in bladder cancer.
    • This impacts the understanding of bladder cancer pathogenesis and potential therapeutic targets.
    • Researchers should exercise caution and disregard the conclusions presented in the retracted article.

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