The journeys of patients with trigeminal neuralgia on a background of multiple sclerosis
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Updated: Nov 2, 2025

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
Krupali Patel1, Kimia Godazandeh2, Jianhua Wu3
1Oral Medicine & Facial Pain Unit Royal National Ear Nose & Throat & Eastman Dental Hospitals, UCLH NHS Foundation Trust, 47-49 Huntley Street, London, WC1E 6DG, UK.
Abstract:
Aim: Multiple sclerosis (MS) is well recognized as a secondary cause for trigeminal neuralgia (TN). In this case series, we detail the management of all the patients with TN and MS (pwTNMS) presenting to a specialist unit. Materials & methods: A prospective patient database was used to extract key clinical data on pharmacological, psychometric and surgical management of 20 pwTNMS. Results: 65% of pwTNMS underwent surgical interventions for management of their pain.12/20 achieved remission periods, through surgery and/or medication. Significant improvement was noted on the global impression of change illustrated by a p < 0.001. Conclusion: pwTNMS require a multifaceted approach combining polypharmacy, surgical interventions and psychological support. Developing self-management skills is crucial if patients are to live well with pain.
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