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Ocular surface temperature differences in glaucoma
Ari Leshno1,2,3, Ori Stern1,2, Yaniv Barkana1,2
1The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel.
European Journal of Ophthalmology
|June 9, 2021
Summary
Glaucoma patients exhibit elevated ocular surface temperature (OST) compared to healthy individuals, suggesting inflammation plays a role in optic nerve damage. Thermographic imaging can detect these temperature differences, aiding glaucoma research.
Area of Science:
- Ophthalmology
- Immunology
- Medical Imaging
Background:
- Neuroinflammation and immune responses are implicated in optic nerve damage in glaucoma.
- Thermographic imaging can detect temperature changes associated with inflammation.
Purpose of the Study:
- To investigate the ocular surface temperature (OST) profile in glaucomatous eyes.
- To understand the role of inflammation in glaucoma pathophysiology.
Main Methods:
- Recruited patients with primary open angle glaucoma (POAG) or pseudoexfoliation glaucoma (PXFG) and healthy controls.
- Used a Therm-App thermal imaging camera for OST acquisition.
- Calculated mean temperatures of the medial cantus, lateral cantus, and cornea.
Main Results:
- Glaucomatous eyes showed significantly higher OST than control eyes (mean difference 0.9°C, p < 0.005).
- This difference remained significant after adjusting for age, sex, intraocular pressure, and environmental temperatures.
- Lens status and IOP-lowering medication did not significantly affect OST.
Conclusions:
- Elevated OST in glaucoma supports the link between inflammation and disease pathophysiology.
- Further longitudinal studies are needed to assess the prognostic value of thermography in glaucoma.
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