[Therapeutic Effect of Convalescent Plasma Transfusion on Fulminant Viral Infectious Diseases--Review]

Area of Science:

• Infectious Diseases
• Virology
• Immunology

Background:

• The COVID-19 pandemic emerged in late 2019, rapidly spreading globally.
• Specific antiviral drugs for COVID-19 are currently limited.
• Convalescent plasma therapy is being explored as a potential treatment option.

Purpose of the Study:

• To review clinical studies and case reports of convalescent plasma therapy in previous viral infectious diseases.
• To provide insights and guidance for the application of convalescent plasma therapy in treating COVID-19.
• To clarify uncertainties regarding donor selection, patient suitability, treatment timing, dosage, and treatment efficacy.

Main Methods:

• Literature review of clinical studies and case reports.
• Analysis of convalescent plasma therapy in historical viral outbreaks.
• Synthesis of findings to inform COVID-19 treatment protocols.

Main Results:

• Previous viral disease outbreaks have utilized convalescent plasma therapy with varying success.
• Key parameters such as donor selection, patient criteria, and treatment timing remain areas for optimization.
• The benefits and risks associated with convalescent plasma therapy require further elucidation.

Conclusions:

• Convalescent plasma therapy shows promise as an alternative treatment for COVID-19.
• Evidence from past viral infections suggests the need for standardized protocols.
• Further research is essential to optimize the use of convalescent plasma for COVID-19 patients.