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The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force.

N K LeBrasseur¹, R de Cabo, R Fielding

¹Nathan K. LeBrasseur, Robert and Arlene Kogod Center on Aging and Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA, lebrasseur.nathan@mayo.edu.

The Journal of Frailty & Aging

|June 9, 2021

Summary

Geroscience research aims to delay aging

Keywords:

Aging frailty hallmarks of aging resilience translational research

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Frailty Assessment in an Aging Mouse Model

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Area of Science:

Geroscience
Aging Biology
Gerontology

Background:

The International Conference on Frailty and Sarcopenia Research Task Force convened in March 2020.
The meeting occurred during the COVID-19 pandemic.
Discussions focused on advancing geroscience, which targets aging mechanisms to maintain function and prevent frailty.

Purpose of the Study:

To identify and validate biomarkers for the hallmarks of aging.
To discuss strategies for advancing the interdisciplinary field of geroscience.
To address research gaps in aging and frailty.

Main Methods:

Task force meeting and discussion.
Review of potential biomarkers for aging hallmarks (mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere dysfunction, cellular senescence, epigenetic changes).
Consideration of the FRAILOMICS initiative and the U.S. National Institute on Aging Translational Gerontology Branch's work.

Main Results:

Identified key areas for geroscience research and clinical practice.
Highlighted numerous potential biomarkers for aging.
Acknowledged the FRAILOMICS initiative's role in omics studies.
Noted the U.S. National Institute on Aging's efforts in translating geroscience knowledge into therapies.

Conclusions:

Priorities include biomarker identification and validation for aging hallmarks.
There is a need for improved cellular and animal models in aging research.
Development of more reliable and sensitive measures for aging and frailty is crucial.