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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Growth Hormone Treatment for Adults With Prader-Willi Syndrome: A Meta-Analysis

Anna G W Rosenberg1,2, Caroline G B Passone3,4, Karlijn Pellikaan1,2

  • 1Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, the Netherlands.

The Journal of Clinical Endocrinology and Metabolism
|June 9, 2021
PubMed

Insights

Growth hormone treatment (GHt) is safe for adults with Prader-Willi syndrome (PWS), improving body composition. This may help reduce cardiovascular risks in this population.

Area of Science:

  • Endocrinology
  • Genetics
  • Metabolic Disorders

Background:

  • Prader-Willi syndrome (PWS) shares features with growth hormone (GH) deficiency, including short stature and altered body composition.
  • GH treatment (GHt) is standard for PWS children, improving health and cognition, but its role in adults is less established.

Purpose of the Study:

  • To review current knowledge on the efficacy and safety of GH treatment in adults with Prader-Willi syndrome.

Main Methods:

  • A systematic literature search was conducted across Medline, Embase, and Cochrane Central Register.
  • Included studies were randomized clinical trials (RCTs) and nonrandomized controlled trials (NRCTs) of adults with PWS receiving GHt for ≥6 months.
  • Data extracted included body composition, BMI, cardiovascular markers, bone density, cognition, quality of life, and safety.

Main Results:

  • Nine RCTs and 20 NRCTs were analyzed. GHt over 12 months significantly improved body composition, increasing lean body mass and reducing fat mass.
  • No significant changes were observed in BMI, cholesterol, fasting glucose, or bone mineral density.
  • No major safety concerns were reported with GHt in PWS adults.

Conclusions:

  • GH treatment appears safe and beneficial for improving body composition in adults with Prader-Willi syndrome.
  • Enhanced body composition may potentially lower the high incidence of cardiovascular morbidity associated with PWS.
  • Further research may solidify GHt as a therapeutic option for adults with PWS.
Abstract

Keywords:
Prader-Willi syndromebody compositioncardiovasculargrowth hormone

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