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Updated: Jun 26, 2026

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Published on: November 1, 2007

Closed-loop artificial endocrine pancreas from Japan.

Kazuhiro Hanazaki1,2, Nobuhisa Tanioka1,2, Masaya Munekage1,2

  • 1Department of Surgery, Kochi Medical School, Kochi University, Kochi, Japan.

Artificial Organs
|June 9, 2021
PubMed
Summary

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Bedside artificial pancreas (AP) systems in Japan offer stable perioperative glycemic control, reducing complications in surgical patients. This approach differs from wearable APs used in Western countries for diabetes management.

Area of Science:

  • Endocrinology
  • Medical Devices
  • Surgical Care

Background:

  • Artificial pancreas (AP) development varies globally, with Western countries focusing on wearable systems for diabetes management.
  • Japan has developed bedside closed-loop AP systems primarily for perioperative and acute care glycemic control.

Purpose of the Study:

  • To review the evidence for perioperative glycemic control using bedside AP in Japan.
  • To discuss the past, present, and future of this technology in surgical and emergency settings.

Main Methods:

  • Review of scientific evidence on perioperative glycemic control.
  • Analysis of the use of the bedside AP STG-55 (Nikkiso) in Japan since 2010.

Main Results:

  • Conventional perioperative glycemic control faces challenges with hyperglycemia, hypoglycemia, and variability.
Keywords:
artificial pancreasclosed-loopintensive insulin therapyperioperative glycemic controlsurgery

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  • The STG-55 bedside AP achieved stable glycemic control, minimizing glucose fluctuations and reducing postoperative infectious complications.
  • This system demonstrated efficacy in patients undergoing major surgeries.

    • Conclusions:

    • Bedside closed-loop AP systems provide effective perioperative glycemic management in Japan.
    • The technology has shown benefits in reducing complications and improving outcomes for surgical patients.
    • Future advancements require more sophisticated and accessible AP devices for critically ill patients.