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[What do we know about Kawasaki disease and COVID-19?]

Jeffrey James William Alberto Hernandez Arias1, Rosa Elena Herrera de la Hoz2, Pedro Luis Lequerica Segrera3

  • 1ESE Hospital san Juan de Díos, Rio negro, Colombia.

Andes Pediatrica : Revista Chilena De Pediatria
|June 9, 2021
PubMed

Insights

A new multisystem inflammatory syndrome in children (MIS-C) linked to COVID-19 presents similarly to Kawasaki disease. This review explores MIS-C

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Public Health

Background:

  • COVID-19 significantly impacts the pediatric population, mirroring adult disease severity.
  • A novel multisystem inflammatory syndrome (MIS-C) has emerged in children post-COVID-19 exposure.
  • MIS-C shares clinical similarities with Kawasaki disease, presenting as a pediatric cytokine storm.

Purpose of the Study:

  • To review current information on COVID-19 and its association with Kawasaki disease.
  • To elucidate the physiopathology, clinical presentation, and diagnostic criteria of MIS-C.
  • To differentiate MIS-C from Kawasaki disease and discuss potential therapeutic strategies.

Main Methods:

  • Literature review of existing studies on COVID-19 in children.
  • Analysis of case reports and clinical data on MIS-C.
  • Comparative analysis of MIS-C and Kawasaki disease.

Main Results:

  • COVID-19 affects children, leading to MIS-C with Kawasaki-like symptoms.
  • MIS-C is hypothesized to be a manifestation of a cytokine storm in pediatric COVID-19 patients.
  • Key differences between MIS-C and Kawasaki disease are being identified.

Conclusions:

  • MIS-C represents a significant, albeit rare, complication of pediatric COVID-19.
  • Understanding the pathophysiology of MIS-C is crucial for timely diagnosis and treatment.
  • Further research is needed to establish definitive therapeutic interventions for MIS-C.

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