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Is venous thromboembolism a predictable marker in older patients with COVID-19 infection? A single-center

Alfredo De Giorgi1, Carlo Contini2, Salvatore Greco3

  • 1Clinica Medica Unit, Azienda Ospedaliero-Universitaria S. Anna, Ferrara, Italy.

Journal of Infection in Developing Countries
|June 9, 2021
PubMed

Insights

Predicting venous thromboembolism (VTE) in elderly SARS-CoV-2 patients is challenging. Current laboratory tests and risk scores, including D-dimer, did not effectively predict VTE in this population.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Hematology

Background:

  • Venous thromboembolism (VTE) is a significant complication in SARS-CoV-2 patients.
  • Elevated D-dimer levels may indicate hypercoagulability risk.

Purpose of the Study:

  • To evaluate the utility of laboratory exams, risk assessment scores, and comorbidity scores in predicting VTE among SARS-CoV-2 patients admitted to internal medicine.

Main Methods:

  • Assessed 49 elderly patients with suspected VTE.
  • Analyzed medical history, blood chemistry, Padua Prediction Score, MEWS, and mEI.
  • Performed lower limb venous color-doppler ultrasound.

Main Results:

  • 10 (20.4%) patients had deep vein thrombosis (DVT), more frequently females (80%).
  • No association found between DVT and Padua Prediction Score, MEWS, or mEI.
  • D-dimer plasma levels were not associated with DVT.

Conclusions:

  • Predicting and diagnosing VTE in elderly, hospitalized SARS-CoV-2 patients is difficult.
  • Lack of precise biomarkers and validated scores hinders VTE prediction in this cohort.
  • Further research with larger sample sizes is needed.

Keywords:
COVID-19D-dimercomorbidity scoreelderlyvenous thromboembolism

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