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[Relationship between circular RNA and liver disease].

H Q Du1, Y Jiang2, Z G Zhang2

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Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|June 9, 2021
PubMed
Summary

Circular RNAs (circRNAs) are novel non-coding RNAs influencing liver disease development by interacting with microRNAs (miRNAs). This review explores circRNA functions and their role in liver diseases for better clinical guidance.

Keywords:
Biological functionLiver diseaseMechanismRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Hepatology

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs.
  • CircRNAs function as part of the competitive endogenous RNA (ceRNA) network.
  • They interact with microRNAs (miRNAs) and are implicated in various biological processes.

Purpose of the Study:

  • To review the current research progress on circRNAs.
  • To elucidate the biological functions of circRNAs.
  • To explore the association between circRNAs and the pathogenesis of liver diseases.

Main Methods:

  • Literature review of existing research on circRNAs and liver disease.
  • Analysis of studies investigating circRNA-miRNA interactions.
  • Synthesis of findings regarding circRNA's role in liver disease development.

Main Results:

  • CircRNAs are widely distributed in organisms.
  • CircRNAs play a significant role in the occurrence and development of liver diseases.
  • Specific circRNAs have been identified as potential biomarkers or therapeutic targets in liver conditions.

Conclusions:

  • CircRNAs represent a crucial regulatory mechanism in liver disease.
  • Understanding circRNA biology can offer new insights into liver disease pathogenesis.
  • Further research into circRNAs may guide improved clinical diagnosis and treatment strategies for liver diseases.