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Warfarin Anticoagulation and Fetal Central Nervous System Abnormalities: a Case Report
Background:
Anticoagulation of pregnant woman with mechanical prosthetic heart valves is associated with significant maternal and fetal risks.
Methods:
We describe a case of dorsal midline dysplasia in a fetus at 11 weeks' gestation. The mother was receiving warfarin therapy at a dose of 7.5 mg daily following a mechanical mitral valve replacement for rheumatic heart disease.
Results:
Histological assessment revealed a meningocele with hemorrhage. No cerebellar or cerebral tissue was present in the skull confirming anencephaly.
Conclusions:
A multidisciplinary approach in pregnant women with mechanical prosthetic heart valves is essential in order to improve fetal outcomes.
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