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Profiling Inflammatory Cytokines in a Cohort Study of Egyptian Patients with COVID-19 Infection
Insights
Elevated inflammatory biomarkers like IL-6, CRP, ferritin, LDH, and D-dimer correlate with COVID-19 severity. These markers, along with older age, male gender, and chronic disease, are key risk factors for severe coronavirus disease 2019.
Area of Science:
- Infectious Diseases
- Immunology
- Biomarkers
Background:
- The COVID-19 pandemic presents a global health crisis, exacerbated by cytokine storm syndrome.
- Understanding risk factors and inflammatory responses is crucial for managing severe cases.
Purpose of the Study:
- To evaluate inflammatory biomarkers in COVID-19 patients.
- To identify risk factors associated with COVID-19 severity.
Main Methods:
- A cross-sectional study involving 150 Egyptian COVID-19 patients.
- Patients categorized by disease severity (mild, moderate, severe) based on clinical and CT findings.
- Laboratory analysis of serum inflammatory biomarkers.
Main Results:
- A significant negative correlation was observed between oxygen saturation and serum inflammatory markers.
- Interleukin-6 (IL-6), C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), and D-dimer showed significant correlations with severity.
- These biomarkers can indicate the risk of severe COVID-19 infection.
Conclusions:
- Risk factors for severe COVID-19 include older age, male gender, and pre-existing chronic conditions.
- Elevated levels of CRP, LDH, ferritin, IL-6, and D-dimer are associated with increased COVID-19 severity.
- These inflammatory markers are valuable for assessing the risk of severe infection.
Background:
Coronavirus disease 2019 (COVID-19) pandemic is an international public health emergency with major disruptions and devastating health consequences resulting from the associated cytokine storm syndrome. The aim of our research was to assess the inflammatory biomarkers and risk factors associated with severity of (COVID-19) patients.
Methods:
A cross-sectional study was conducted and included 150 Egyptian patients with COVID-19. Patients were classified into mild, moderate, and severe according to the clinical and CT chest findings. Blood samples were collected from patients for laboratory assessment of inflammatory biomarkers.
Results:
Our results showed significant negative correlation between oxygen saturation percent and serum levels of inflammatory markers. The correlations were statistically significant with IL-6, CRP, ferritin, LDH, and D-dimer which can be used as sensitive biomarkers for assessment of the risk of severity of infection in COVID 19 patients.
Conclusions:
The study revealed that the risk factors associated with severity of COVID 19 infection included older age, male gender, presence of underlying chronic disease, and increased levels of inflammatory biomarkers: CRP, LDH, ferritin, IL-6, and D-dimer.
