Related Experiment Video
Updated: Nov 2, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
467
Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis
Tengteng Wang1,2, Maryam S Farvid2, Jae H Kang3
1Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital, and Harvard Medical School, Boston, Massachusetts. tengteng.wang@channing.harvard.edu.
Cancer Research
|June 10, 2021
Summary
Adhering to a diabetes risk reduction diet (DRRD) after breast cancer diagnosis significantly lowers mortality risk. Improving diet post-diagnosis is linked to better breast cancer survival and overall health outcomes.
Area of Science:
- Oncology
- Endocrinology
- Nutritional Science
Background:
- Type II diabetes is linked to poorer breast cancer prognosis.
- Dietary interventions may impact survival outcomes for breast cancer patients.
Purpose of the Study:
- To investigate the association between a diabetes risk reduction diet (DRRD) and survival in breast cancer patients.
- To assess the impact of postdiagnosis dietary modifications on breast cancer-specific and all-cause mortality.
Main Methods:
- Followed 8,482 women with breast cancer from two large cohort studies.
- Assessed diet using validated questionnaires every 2-4 years, calculating a cumulative average DRRD score.
- Utilized Cox proportional hazards models to estimate mortality risks, adjusting for confounders.
Main Results:
- Higher adherence to DRRD postdiagnosis was associated with a 20% lower risk of breast cancer-specific mortality (HR=0.80; 95% CI=0.65-0.97).
- Higher DRRD adherence also correlated with a 34% lower risk of all-cause mortality (HR=0.66; 95% CI=0.58-0.76).
- Women improving their DRRD score postdiagnosis showed reduced mortality risks compared to those with consistently low scores.
Conclusions:
- Greater adherence to the DRRD after breast cancer diagnosis is associated with improved survival.
- Dietary modifications aligned with type II diabetes prevention may be crucial for breast cancer survivors' outcomes.
Related Concept Videos
02:59Cancer Prevention
7.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.1K
01:21Cancer Survival Analysis
491
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
491
01:22Diabetes Mellitus: Type 2 and Gestational
3.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.6K
01:19Psychoneuroimmunology: Diabetes and Cancer
106
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
106
01:15Diabetes: Management and Pharmacotherapy
652
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
652
01:36Carbohydrate Metabolism
12.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
12.8K