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[Primary breast diffuse large B-cell lymphoma in an elderly man maintaining long-term complete response]
Shinsuke Noguchi1, Hirobumi Saitoh1, Hideto Sasaki2
1Department of Hematology, Akita Red Cross Hospital.
Summary
Primary breast diffuse large B-cell lymphoma (DLBCL) is rare, typically affecting women. This case highlights a 65-year-old man with breast DLBCL, emphasizing early diagnosis and CNS recurrence prevention.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's lymphoma.
- It predominantly affects women, making male cases exceptionally uncommon.
Observation:
- A 65-year-old male presented with a right breast lump and axillary lymphadenopathy.
- Initial diagnosis was suspected breast cancer with metastasis; needle biopsy confirmed malignant lymphoma.
- Histological confirmation of primary breast DLBCL, germinal center B-cell type, clinical stage IIA was achieved post-resection.
Findings:
- The patient received six cycles of R-CHOP therapy combined with intrathecal injections for central nervous system (CNS) prophylaxis.
- Achieved complete remission lasting 5 years post-treatment.
Implications:
- Breast lymphoma can occur in men, necessitating early histological diagnosis.
- Effective CNS recurrence prevention strategies are crucial in managing breast DLBCL, regardless of patient sex.
