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Updated: Nov 2, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Structural insight on assembly-line catalysis in terpene biosynthesis.

Jacque L Faylo1, Trevor van Eeuwen2,3, Hee Jong Kim2,3

  • 1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States.

Nature Communications
|June 10, 2021
PubMed
Summary

Fusicoccadiene synthase (PaFS) is a unique enzyme. Its structure reveals how it channels substrates for Fusicoccin A biosynthesis, a key 14-3-3 protein interaction mediator.

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