A three-component iodine-catalyzed oxidative coupling reaction: a heterodifunctionalization of 3-methylindoles
Wei Zhang1, Shiqun Xiang2, Weibin Fan2
1Fujian Normal University, College of Chemistry and Materials Science, Fuzhou 350007, China. dhuang@fjirsm.ac.cn and State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
Abstract:
A metal-free method for the synthesis of heterodifunctional indole derivatives is developed through TBHP/KI-mediated oxidative coupling. The reaction constructs C-O and C-C bonds in succession with the help of tert-butyl peroxy radicals generated by the TBHP/KI catalytic system, enabling the direct realization of the heterodifunctionalization of indole in one pot. The product of this reaction is a novel heterodifunctional compound. This work might provide a new effective method for the synthesis of polycyclic indole compounds.
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