Early concerns in parents of infants at risk for autism

Amanda T Tran1, Mithi Del Rosario1,2, Erin Nosco3

  • 1David Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

Insights

Parents of high-risk infants for autism spectrum disorder (ASD) began reporting concerns by 6 months. By 12 months, parents of atypically developing high-risk infants identified ASD-related concerns, aiding early detection.

Area of Science:

  • Developmental Pediatrics
  • Autism Spectrum Disorder Research
  • Child Psychology

Background:

  • Early identification of autism spectrum disorder (ASD) is crucial for timely intervention.
  • Parental concerns are a key indicator in monitoring infant development, particularly in high-risk populations.
  • Familial risk significantly influences the likelihood of developing ASD.

Purpose of the Study:

  • To investigate parental concerns in infants with a high familial risk of ASD.
  • To track the emergence and nature of ASD-related and general concerns over the first 18 months of life.
  • To differentiate concerns based on infant outcome (typically developing vs. atypically developing) within the high-risk group.

Main Methods:

  • Prospective collection of parental concerns (ASD-related and general) from 76 infants (high-risk and low-risk) at multiple time points (1.5 to 18 months).
  • Outcome classification at 36 months.
  • Statistical analysis using generalized linear mixed models and qualitative evaluation.

Main Results:

  • Most parents reported no concerns in early infancy (1.5 and 3 months).
  • By 6 months, parents of high-risk infants reported significantly more ASD-related and general concerns than low-risk infants.
  • By 12 months, parents of high-risk infants who later developed atypically showed more ASD-related concerns than those who developed typically.

Conclusions:

  • Clinicians should actively inquire about parental concerns by 6 months in high-risk infants.
  • Parental identification of ASD-suggestive concerns by 12 months can facilitate earlier screening and intervention.
  • Parental insights are valuable in monitoring developmental trajectories for early ASD detection.
Abstract

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