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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry
Junjie Zhong1, Wendi Xuan1, Mengting Tang1
1School of Life Science, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
Abstract:
ANO1, anoctamin 1(also known as TMEM16A), is the molecular basis of calcium-activated chloride channels with ten transmembrane segments which are widely expressed in mammalian cells, including epithelial cells, vascular smooth muscle tissues, electro-excitatory cells, and some tumor cells. To date, multiple studies have shown that many natural and synthetic compounds have regulatory effects on ANO1. Therefore, ANO1 could be a potential new drug target for the treatment of cancer, pain, diarrhea, hypertension, and asthma. In this study, we review the structure of ANO1 and its involvement in cancer, pain, diarrhea, hypertension, and asthma.
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