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Cell-mediated Immune Responses

Cell-mediated Immune Responses

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Nov 2, 2025

In Vitro Assay to Study Tumor-macrophage Interaction

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

Macrophages as a "weapon" in anticancer cellular immunotherapy.

Dmitry Aminin^1,2, Yun-Ming Wang^3,4

¹G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia.

The Kaohsiung Journal of Medical Sciences

|June 10, 2021

Summary

Anticancer immunotherapy uses activated M1 macrophages to target tumors, offering a promising approach for personalized cancer treatment with high specificity and fewer side effects. This review explores their potential in cellular immunotherapy.

Keywords:

M1 phenotype anticancer cellular immunotherapy cancer macrophages

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Published on: October 20, 2016

Area of Science:

Immunology
Oncology
Cellular Therapy

Background:

Anticancer immunotherapy activates the immune system to combat tumors, offering advantages like specificity and low side effects.
Macrophages are increasingly explored for adoptive cell therapy in cancer treatment.
M1 macrophages show tumoricidal activity, while M2 macrophages support tumor evasion.

Purpose of the Study:

To discuss modern applications of activated M1 macrophages in anticancer therapy.
To review recent publications (up to 2021) on M1 macrophage-based cancer treatment.

Main Methods:

Review of scientific literature up to 2021.
Focus on M1 macrophage activation and tumoricidal properties.
Discussion of adoptive cell therapy strategies.

Main Results:

M1 macrophages exhibit significant tumoricidal activity, making them effective for immunotherapy.
Activated M1 macrophages hold promise for personalized cancer therapy.
Macrophage-directed therapy is a rapidly advancing field in oncology.

Conclusions:

Activated M1 macrophages are a potent tool in anticancer cellular immunotherapy.
Personalized therapy using M1 macrophages presents a promising future for cancer treatment.
Further research into macrophage-based therapies is warranted.