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Altered chemosensitivity to CO2 during exercise.

Stanley M Yamashiro1, Takahide Kato2, Takaaki Matsumoto3

  • 1Biomedical Engineering Department, University of Southern California, Los Angeles, CA, USA.

Physiological Reports
|June 10, 2021
PubMed
Summary
This summary is machine-generated.

Exercise significantly enhances carbon dioxide (CO2) chemosensitivity, particularly via peripheral receptors. This improved sensitivity contributes to augmented ventilation, potentially linked to long-term facilitation during physical activity.

Keywords:
CO2 inhalationchemosensitivityexercise

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Area of Science:

  • Physiology
  • Respiratory Control
  • Exercise Science

Background:

  • The impact of exercise on carbon dioxide (CO2) chemosensitivity remains debated.
  • Previous studies using rebreathing methods for CO2 alteration are poorly tolerated during exercise.

Purpose of the Study:

  • To investigate the effects of exercise on chemosensitivity to CO2.
  • To differentiate the roles of central and peripheral chemosensitivity during exercise.
  • To explore the potential for long-term facilitation (LTF) of ventilation.

Main Methods:

  • Seven healthy subjects inhaled a fixed 3% CO2 mixture from rest to moderate exercise.
  • Ventilatory responses were measured during CO2 inhalation and during exercise with normal air.
  • Mathematical modeling was used to assess central and peripheral chemosensitivity contributions.

Main Results:

  • CO2 chemosensitivity was significantly enhanced during mild exercise after 5-6 minutes of stimulation (p < 0.01).
  • Inhaling 3% CO2 during moderate exercise induced ventilation augmentation consistent with LTF after 6 minutes (p < 0.01).
  • Peripheral chemoreceptors demonstrated a dominant role in the increased chemosensitivity during exercise, a novel finding.

Conclusions:

  • Both central and peripheral chemosensitivity to CO2 increase during exercise.
  • Peripheral chemoreceptors play a more significant role in exercise-induced chemosensitivity changes.
  • Chemoreceptor stimulation during exercise can lead to augmented ventilation, indicative of LTF.