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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii
Jian-Fa Zong1, Meng-Meng Zhang2, Yu-Bo Zhou2
1School of Pharmacy, Fudan University, Shanghai 201203, China.
Abstract:
Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC50 values from 6.63 ± 2.40 to 14.21 ± 3.51 μM.
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