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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
06:41

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

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Characteristics and outcomes of patients with COVID-19 supported by extracorporeal membrane oxygenation: A

Omar Saeed1, Antone J Tatooles2, Muhammad Farooq1

  • 1Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

The Journal of Thoracic and Cardiovascular Surgery
|June 11, 2021
PubMed

Insights

In patients with severe COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support, mortality was 42% at 90 days. Age, renal dysfunction, and CPR before ECMO predicted death.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Cardiopulmonary Support

Background:

  • Severe COVID-19 can necessitate advanced respiratory support.
  • Extracorporeal membrane oxygenation (ECMO) is a critical intervention for refractory respiratory failure.

Purpose of the Study:

  • To identify characteristics and clinical factors associated with mortality in COVID-19 patients receiving ECMO.
  • To evaluate the outcomes of ECMO in severe COVID-19 cases.

Main Methods:

  • A multicenter, retrospective cohort study of adult COVID-19 patients requiring ECMO.
  • In-hospital mortality at 90 days was the primary outcome.
  • Multivariable Cox regression identified factors associated with mortality.

Main Results:

  • The cohort included 292 patients; 39% died during hospitalization.
  • The 90-day in-hospital mortality rate was 42%.
  • Increased age, renal dysfunction, and pre-ECMO CPR were associated with higher mortality.

Conclusions:

  • In-hospital mortality for COVID-19 patients on ECMO was less than 50%.
  • ECMO can be a viable treatment for severe, refractory COVID-19.
  • Identifying risk factors aids in managing ECMO patients.
Abstract

Keywords:
ARDSCOVID-19ECMOmortality

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