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Pneumocystis jirovecii pneumonia as a complication of etoposide therapy
Maria Alejandra Mendoza1, Sunil Iyer2, Jose F Camargo3
1Internal Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA maria.mendoza2@jhsmiami.org.
Abstract:
Two patients receiving oral etoposide therapy developed Pneumocystis jirovecii pneumonia during chemotherapy with significant lymphopenia without corticosteroid use. In this commentary we discuss cellular mechanisms by which etoposide induced CD4+ T lymphocyte dysfunction and reduced survival may lead to predisposition to P. jirovecii infection.
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