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Updated: Nov 2, 2025
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary
Carolin Kirsten1, Manja Unrath1, Christian Lück2
1Department of Pediatrics, Technische Universität Dresden, Dresden, Germany.
Objective:
To quantify the number of SARS-CoV-2 infections in secondary schools after their reopening in May 2020.
Design:
Repeated SARS-CoV-2 seroprevalence study after the reopening of schools and 4 months later.
Setting:
Secondary school in Dresden, Germany.
Participants:
1538 students grades 8-12 and 507 teachers from 13 schools.
Interventions:
Serial blood sampling and SARS-CoV-2 IgG antibody assessment.
Primary And Secondary Outcome Measure:
Seroprevalence of SARS-CoV-2 antibodies in study population. Number of undetected cases.
Results:
1538 students and 507 teachers were initially enrolled, and 1334 students and 445 teachers completed both study visits. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in September/October. Even in schools with reported COVID-19 cases before the lockdown of 13 March, no clusters could be identified. Of 12 persons with positive serology five had a known history of confirmed COVID-19; 23 out of 24 participants with a household history of COVID-91 were seronegative.
Conclusions:
Schools do not play a crucial role in driving the SARS-CoV-2 pandemic in a low-prevalence setting. Transmission in families occurs very infrequently, and the number of unreported cases is low in this age group. These observations do not support school closures as a strategy fighting the pandemic in a low-prevalence setting.
Trial Registration Number:
DRKS00022455.
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