Early-phase ¹⁸F-FP-CIT and ¹⁸F-flutemetamol PET were significantly correlated

Little is known about whether early-phase PET images of ¹⁸F-FP-CIT match those of amyloid PET. Here, we compared early-phase ¹⁸F-FP-CIT and ¹⁸F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase ¹⁸F-FP-CIT PET (median, 0.86) was significantly lower than that of ¹⁸F-flutemetamol PET (median, 0.91, p < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures (p = 0.232). The SUVR of total brain regions obtained from early ¹⁸F-FP-CIT PET showed a very strong correlation with that of ¹⁸F-flutemetamol PET (rho = 0.80, p < 0.001). Among the kinetic parameters, only R1 showed a statistically significant correlation between the two techniques for all brain regions (rho = 0.89, p < 0.001). R1 from ¹⁸F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to R1 from ¹⁸F-flutemetamol PET (median, 0.81, p < 0.001).¹⁸F-FP-CIT demonstrated lower uptake in cortical brain regions than ¹⁸F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.