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Association Between Blood Pressure Indicators and Stroke in Aged Population: A Community-Based Nested Case-Control
Longbing Ren1,2, Yan Gao3, Yuting Jiang3
1Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Tongji University, Shanghai, 200120, People's Republic of China.
Single blood pressure measurements are insufficient for predicting cardiovascular events. This study found that systolic blood pressure and pulse pressure independently increase stroke risk, highlighting the need for comprehensive assessment in stroke prevention.
Area of Science:
- Cardiovascular epidemiology
- Public health research
- Clinical hypertension
Background:
- A single blood pressure measurement is inadequate for estimating adverse cardiovascular events.
- Comprehensive investigation of blood pressure indicators and stroke association is needed.
Purpose of the Study:
- To investigate the association between various blood pressure indicators and stroke risk.
- To identify specific blood pressure metrics that independently predict stroke.
Main Methods:
- An observational cohort study of 2888 Shanghai residents (2014-2018).
- A nested case-control study with 415 stroke cases and 415 matched controls.
- Multivariate logistic regression analysis was employed.
Main Results:
- Systolic blood pressure (SBP), pulse pressure (PP), mean arterial pressure (MAP), and pulse pressure index (PPI) were associated with increased stroke risk.
- Isolated abnormal SBP and PP ≥50 mmHg independently increased stroke risk.
- Adjusted odds ratios (AOR) indicated significant associations for SBP, PP, MAP, and PPI.
Conclusions:
- Beyond SBP and PP, a comprehensive assessment of multiple factors is crucial for stroke prevention and management.
- Elevated SBP and PP are significant independent risk factors for stroke.
- Current blood pressure assessment methods may need enhancement for effective stroke risk prediction.
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