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Updated: Nov 2, 2025

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
Echocardiographic Parameters Predict Short- and Long-Term Adverse Cardiovascular Events in Patients with Acute
Meng-Meng Han1, Wen-Shu Zhao2, Xin Wang2
1Intensive Care Units, Beijing Longfu Hospital, Beijing, 100010, People's Republic of China.
Insights
Echocardiography can predict adverse cardiovascular events after acute myocardial infarction. Left ventricular ejection fraction (LVEF) predicts short-term outcomes, while wall motion score index (WMSI) and E/E' ratio predict long-term outcomes.
Area of Science:
- Cardiology
- Medical Imaging
- Predictive Analytics
Background:
- Acute myocardial infarction (AMI) poses significant risks for adverse cardiovascular events.
- Early identification of high-risk patients is crucial for effective management.
- Echocardiography is a key diagnostic tool in cardiology.
Purpose of the Study:
- To identify echocardiographic parameters predicting short- and long-term adverse cardiovascular events in AMI patients.
- To evaluate the prognostic value of specific echocardiographic indices.
Main Methods:
- 126 AMI patients underwent echocardiography within 12 hours of admission.
- Follow-up was conducted for up to 5 years to record major adverse cardiovascular events (MACEs).
- Statistical analysis included logistic regression and area under the curve (AUC) calculations.
Main Results:
- Left ventricular ejection fraction (LVEF) < 40% predicted 1-year MACEs (AUC=0.676).
- For 5-year MACEs, E/E' ratio > 15 (AUC=0.691) and wall motion score index (WMSI) > 1.5 (AUC=0.691) were significant predictors.
- These echocardiographic parameters demonstrated significant predictive capabilities for cardiovascular events.
Conclusions:
- LVEF is a valuable predictor of short-term outcomes (1-year) post-AMI.
- WMSI and E/E' ratio are effective in predicting long-term outcomes (5-year) in AMI patients.
- Echocardiography provides essential prognostic information for managing AMI patients.
Objective:
This study aimed to find echocardiographic parameters that can predict short- and long-term adverse cardiovascular events in patients with AMI.
Methods:
A total of 126 patients with AMI admitted to our hospital from July to December 2012 were enrolled in this study. All patients underwent echocardiographic examination within 12 hours after admission and received regular follow-ups until December 2018. The primary endpoint was a composite of the major adverse cardiovascular events (MACEs).
Results:
In the first year of this study, a primary endpoint occurred in 35 patients and the predictor derived from the echocardiography of 1-year primary endpoint was LVEF<40% (OR: 9.000, 95% CI 3.242-24.987, p<0.0001) and the area under the curve (AUC) for the predictor was 0.676 (95% CI 0.561-0.790, p=0.002). For the total 5 years, 57 patients underwent primary endpoint. The results of the 5-year primary endpoint were: E/E'>15 (OR: 4.094, 95% CI 1.726-9.710, P=0.001), the wall motion score index was (WMSI)>1.5 (OR: 12.791, 95% CI 1.511-108.312, P=0.019), and the AUC was 0.691 (95% CI 0.595-0.787 P<0.0001).
Conclusion:
LVEF is correlated with a short-term outcome (1-year), and WMSI and E/E' can predict a long-term outcome (5-year) in patients with acute myocardial infarction.
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