Related Experiment Video
Updated: Nov 2, 2025
07:15
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
618
IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report
Alessandro Pezzutto1, Vittorio Sirolli1, Lorenzo Di Liberato1
1Department of Medicine, Nephrology and Dialysis Unit, SS Annunziata Hospital, "G. d'Annunzio" University, Chieti, Italy.
International Medical Case Reports Journal
|June 11, 2021
Summary
Immunoglobulin A deficiency (IgAD) is linked to autoimmune diseases. This case highlights IgAD’s association with nephrotic syndrome due to membranoproliferative glomerulonephritis in a young patient.
Area of Science:
- Nephrology
- Immunology
Background:
- Immunoglobulin A deficiency (IgAD) is the most prevalent primary immunodeficiency in Western nations.
- IgAD is increasingly recognized for its association with autoimmune conditions in pediatric and adult populations, though underlying mechanisms remain unclear.
Observation:
- A pediatric case presented with nephrotic syndrome attributed to membranoproliferative glomerulonephritis.
- The patient was incidentally diagnosed with IgAD concurrently with the nephrotic syndrome.
Findings:
- Treatment with corticosteroids and angiotensin-converting enzyme inhibitors yielded partial remission of nephrotic syndrome.
- Despite initial improvement, progressive decline in renal function was observed during follow-up.
Implications:
- This case expands the known spectrum of glomerulonephritis associated with IgAD.
- Further research is warranted to elucidate the pathophysiology linking IgAD and glomerulonephritis.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
228
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
228
01:26Nephrotic Syndrome II : Assessment and Medical Management
49
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
49
01:24Nephrotic Syndrome III : Nursing Management
91
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
91
01:24Chronic Kidney Disease II: Clinical Manifestations
224
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
224
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
97
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
97
01:22Acute Kidney Injury I: Introduction
221
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
221