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Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Related Experiment Video

Updated: Nov 2, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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COVID-19-Associated Pneumonia: Radiobiological Insights.

Sabine François1, Carole Helissey2, Sophie Cavallero1

  • 1Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Brétigny-sur-Orge, France.

Frontiers in Pharmacology
|June 11, 2021
PubMed
Summary

Low-dose ionizing radiation may help manage severe COVID-19 by modulating the cytokine storm and preventing complications. Further research is needed to explore this potential therapeutic approach for acute respiratory distress syndrome.

Keywords:
SARS-CoV-2 pneumoniaimmune systemradiation therapyradiation-induced cancersradiobiology

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Area of Science:

  • Immunology
  • Virology
  • Radiology

Background:

  • COVID-19 pneumonia can progress to acute respiratory distress syndrome (ARDS) due to a virus-induced cytokine storm.
  • This storm involves systemic inflammation, endothelial damage, and immune dysregulation, contributing to severe disease and potential long-term tissue damage.
  • Current strategies focus on vaccines, but alternative or complementary therapies are needed, especially with emerging variants.

Purpose of the Study:

  • To explore the potential of low-dose ionizing radiation (LDIR) as a therapeutic strategy for COVID-19.
  • To investigate LDIR's ability to modulate the cytokine storm and mitigate secondary complications in severe COVID-19.

Main Methods:

  • Review of preliminary physiopathological and experimental data on LDIR effects.
  • Discussion of preclinical findings suggesting LDIR's anti-inflammatory properties.

Main Results:

  • Preclinical data suggest LDIR may modulate the inflammatory storm associated with COVID-19.
  • LDIR shows potential in preventing secondary complications from vascular endothelial damage and immune deregulation.

Conclusions:

  • LDIR presents a potential therapeutic avenue for managing severe COVID-19 and ARDS.
  • While evidence is preliminary, LDIR warrants further investigation as a complementary strategy to vaccines and other treatments.