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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

508
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
508

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Related Experiment Video

Updated: Nov 2, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
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Microbiota and Microglia Interactions in ASD.

Marcela Davoli-Ferreira1, Carolyn A Thomson1, Kathy D McCoy1

  • 1Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Frontiers in Immunology
|June 11, 2021
PubMed
Summary
This summary is machine-generated.

Altered microglial cell function, influenced by gut microbiota, may contribute to autism spectrum disorder (ASD) etiology. Environmental factors impact microglia, potentially linking gut health to ASD development and behavioral symptoms.

Keywords:
autism spectrum disorder (ASD)dysbiosisinflammationmicrobial metabolitesmicrobiomemicroglianeurodevelopmental disorders

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Related Experiment Videos

Last Updated: Nov 2, 2025

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Area of Science:

  • Neuroscience
  • Immunology
  • Microbiology

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with poorly understood neurobiological underpinnings.
  • Microglia, the brain's resident immune cells, play critical roles in brain development and homeostasis, but their specific involvement in ASD remains unclear.
  • The gut microbiota is increasingly recognized for its influence on brain function and behavior, including potential roles in neurodevelopmental disorders.

Purpose of the Study:

  • To explore the mechanisms by which microglial dysfunction may contribute to ASD etiology.
  • To investigate the role of the gut microbiota in modulating microglial function and its potential impact on ASD.
  • To examine how environmental stimuli influence microglial phenotype and function in the context of ASD.

Main Methods:

  • Review of current literature on microglial function, gut microbiota, and ASD.
  • Analysis of emerging data linking intestinal dysbiosis to ASD behavioral changes.
  • Exploration of environmental factors influencing microglial cell phenotype and function.

Main Results:

  • Alterations in microglial cell functions are implicated as potential drivers of neurodevelopmental disorders like ASD.
  • The gut microbiota significantly influences microglial maturation and activation.
  • Intestinal dysbiosis is frequently observed in ASD patients, and microbiome-targeted therapies show promise in alleviating behavioral symptoms.

Conclusions:

  • Reciprocal interactions between microglia and the gut microbiota are crucial in ASD etiology.
  • Environmental factors, including those affecting the gut microbiome, can modulate microglial function, offering potential therapeutic avenues for ASD.
  • Further research into the microglia-gut-brain axis is warranted to understand and treat ASD.