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Intensive plasma exchange, complement dependent microcytotoxicity and renal transplant rejection
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1977
Summary
Intensive plasma exchange (IPE) temporarily reversed humoral rejection in renal transplant recipients unresponsive to steroids. However, this intensive plasma exchange did not improve long-term graft survival rates.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- Humoral rejection is a significant cause of renal transplant failure.
- Conventional therapies like high-dose steroids are often insufficient for severe rejection episodes.
Purpose of the Study:
- To evaluate the efficacy of intensive plasma exchange (IPE) in treating renal transplant recipients experiencing biopsy-proven humoral rejection.
- To assess the impact of IPE on graft survival in patients refractory to standard anti-rejection treatments.
Main Methods:
- Intensive plasma exchange (IPE) was administered to eight renal transplant recipients with 13 episodes of biopsy-proven humoral rejection.
- Patients had previously failed to respond to high-dose steroid therapy.
Main Results:
- IPE resulted in the reversal of 7 out of 13 rejection episodes (response in 5 of 8 patients).
- Two grafts maintained adequate function at 6 and 8 months post-IPE.
- IPE demonstrated a temporary effect on rejection reversal.
Conclusions:
- Intensive plasma exchange can temporarily reverse humoral rejection in renal transplant recipients.
- IPE does not appear to improve long-term renal allograft survival in this patient cohort.