Consolidated lung on contrast-enhanced chest CT: the use of spectral-detector computed tomography parameters in...

To investigate the value of spectral-detector computed tomography (SDCT) parameters for the quantitative differentiation between atelectasis and pneumonia on contrast-enhanced chest CT.

Sixty-three patients, 22 clinically diagnosed with pneumonia and 41 with atelectasis, underwent contrast-enhanced SDCT scans during the venous phase. CT numbers (Hounsfield Units [HU]) were measured on conventional reconstructions (CON_120kVp) and the iodine concentration (C_iodine, [mg/ml]), and effective atomic number (Z_eff) on spectral reconstructions, using region-of-interest (ROI) analysis. Receiver operating characteristics (ROC) and contrast-to-noise ratios (CNRs) were calculated to assess each reconstruction's potential to differentiate between atelectasis and pneumonia.

On contrast-enhanced SDCT, the difference between atelectasis and pneumonia was significant on CON_120kVp, C_iodine, and Z_eff images (p < 0.001). On CON_120kVp images, a threshold of 81 HU achieved a sensitivity of 93 % and a specificity of 95 % for identifying pneumonia, while C_iodine and Z_eff images reached the same sensitivity but lower specificities of 85 % and 83 %. CON_120kVp images showed significantly higher CNRs between normal lung and atelectasis or pneumonia with 30.63 and 27.69 compared to C_iodine images with 3.54 and 1.27 and Z_eff images with 4.22 and 7.63 (p < 0.001). None of the parameters could differentiate atelectasis and pneumonia without contrast media.

Contrast-enhanced SDCT can differentiate atelectasis and pneumonia based on the spectral parameters C_iodine, and Z_eff. However, they had no added value compared to CT number measurement on CON_120kVp images. Furthermore, contrast media is still needed for a differentiation based on quantitative SDCT parameters.