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The association between left ventricular mass index and serum sirtuin 3 level in patients with hypertension

Orhan Karayiğit1, Muhammet Cihat Çelik2, Emrullah Kiziltunç1

  • 1Department of Cardiology, Numune Education and Research Hospital.

Cardiovascular Endocrinology & Metabolism
|June 11, 2021
PubMed

Insights

Serum SIRT3 levels did not correlate with left ventricular mass index (LVMI) in hypertensive patients. However, SIRT3 levels were associated with myocardial systolic velocity, indicating early diastolic dysfunction.

Area of Science:

  • Cardiology
  • Biochemistry
  • Hypertension Research

Background:

  • Sirtuin 3 (SIRT3) is recognized for its protective role against oxidative stress and cardiac hypertrophy in cardiomyocytes.
  • Hypertension is a significant risk factor for cardiac remodeling, including left ventricular hypertrophy.

Purpose of the Study:

  • To investigate the potential relationship between serum SIRT3 levels and left ventricular mass index (LVMI) in patients diagnosed with hypertension.
  • To explore the association of SIRT3 with cardiac structure and function markers in this population.

Main Methods:

  • A cross-sectional study involving 83 hypertensive patients was conducted.
  • Left ventricular mass index (LVMI) was calculated using American Echocardiography Association guidelines.
  • Patients were stratified into groups with increased and normal LVMI.

Main Results:

  • No significant difference in serum SIRT3 levels was observed between patients with increased LVMI and normal LVMI (P=0.914).
  • Serum pro-brain natriuretic peptide levels were significantly higher in patients with increased LVMI (P=0.019).
  • A positive correlation was found between serum SIRT3 levels and Sm (myocardial systolic) velocity (r=0.338, P=0.002).

Conclusions:

  • Serum SIRT3 levels are not directly correlated with LVMI in hypertensive patients.
  • SIRT3 levels show a positive correlation with Sm velocity, suggesting a potential role in early diastolic dysfunction.
  • These findings suggest SIRT3 may be linked to myocardial function rather than solely hypertrophy in hypertension.
Abstract

Keywords:
hypertensionleft ventricular hypertrophysirtuin

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