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Growth rate in infants with impaired renal function
1Department of Pediatrics, University of California, San Francisco.
The Journal of Pediatrics
|September 1, 1988
Summary
Monitoring growth velocity standard deviation scores in children with reduced renal function provides insight into growth factors. Residual renal function impacts growth, but infections and other issues also play a role.
Area of Science:
- Pediatric Nephrology
- Growth and Development
Background:
- Children with reduced renal function require specialized nutritional support.
- Assessing growth in these children is complex due to various influencing factors.
Purpose of the Study:
- To evaluate changes in renal function and growth rates in children with reduced renal function on a low-phosphorus formula.
- To analyze the relationship between residual renal function, growth velocity, and other clinical factors.
Main Methods:
- Longitudinal monitoring of renal function (serum creatinine, creatinine clearance) and growth (growth velocity standard deviation scores).
- Analysis of factors such as infections, acidosis, and salt wasting impacting growth.
- Assessment of serum parathormone levels in relation to renal function severity.
Main Results:
- Growth velocity standard deviation scores provided a more accurate growth assessment than height standard deviation scores.
- A relationship between residual renal clearance and growth velocity was observed.
- Children with more severe renal impairment had elevated parathormone levels despite formula management.
Conclusions:
- Serial growth velocity standard deviation scores offer valuable insights into growth in children with renal impairment.
- Residual renal function is a key factor for growth potential, but complicating factors significantly influence outcomes.
- Optimizing management of acidosis and salt wasting is crucial for growth in less severely affected children.