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Updated: Nov 2, 2025
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Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation
Published on: March 9, 2018
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Artemisinin-derived dimers from a chemical perspective
Aysun Çapcı1, Lars Herrmann1, Halmuthur M Sampath Kumar1,2
1Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Medicinal Research Reviews
|June 11, 2021
Summary
Artemisinin dimers show significantly improved activity against malaria, cancer, and viruses compared to monomers. These novel compounds are non-toxic to normal cells and offer fewer side effects, highlighting their therapeutic potential.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Drug Discovery
Background:
- Artemisinin and its derivatives are clinically used drugs.
- The dimer approach has emerged as a promising strategy for developing new therapeutic agents.
- Artemisinin dimers exhibit enhanced efficacy and reduced toxicity compared to their monomeric counterparts.
Purpose of the Study:
- To provide an overview of synthetic strategies for artemisinin-derived dimers.
- To highlight the biological activities of these dimer compounds.
- To explore the potential of artemisinin dimers as antimalarial, anticancer, and antiviral agents.
Main Methods:
- Review of recent literature on artemisinin dimer synthesis.
- Analysis of various linking moieties (symmetric and non-symmetric) used in dimer construction.
- Evaluation of biological activities reported for synthesized dimers.
Main Results:
- Significant improvements in activity of artemisinin dimers over monomers against parasites, cancer cells, and viruses.
- Demonstrated lack of toxicity in normal cells for artemisinin dimers.
- Development of diverse synthetic routes for novel artemisinin dimer drug candidates.
Conclusions:
- Artemisinin dimers represent a highly promising class of therapeutic agents.
- The dimerization strategy offers a viable approach to enhance drug efficacy and safety.
- Further research into the synthesis and biological evaluation of artemisinin dimers is warranted.
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