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Related Concept Videos

Tracheostomy: Procedure and Tubes01:28

Tracheostomy: Procedure and Tubes

1.7K
A tracheostomy is a surgical procedure that creates an artificial opening into the trachea, typically at the second or third cartilaginous ring level. This opening allows the insertion of a tracheostomy tube, which can replace an endotracheal tube, provide mechanical ventilation, bypass an upper airway obstruction, or remove accumulated tracheobronchial secretions.
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
1.7K
Tracheostomy Decannulation01:21

Tracheostomy Decannulation

534
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
534

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Related Experiment Video

Updated: Nov 2, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
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Vascularization strategies for tissue engineering for tracheal reconstruction.

Fei Sun1,2,3, Yi Lu1,2,3, Zhihao Wang1,2,3

  • 1Clinical Medical College, Yangzhou University, Yangzhou, 225001, PR China.

Regenerative Medicine
|June 11, 2021
PubMed
Summary

Tissue engineering offers tracheal reconstruction alternatives. This review highlights the crucial role of microvascular network formation in 3D scaffolds for successful graft survival and function.

Keywords:
3D bioprintingbio-inkbiomaterialsdecellularizationextracellular matrixhybrid scaffoldsregenerative medicinetissue engineeringtracheavascularization

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Tissue engineering provides promising alternatives for tracheal reconstruction.
  • Functional microvascular networks are vital for graft survival and cell metabolism.
  • The importance of microvascularization in 3D scaffolds for tracheal tissue engineering has been underappreciated.

Purpose of the Study:

  • To review key technologies for microvascular network construction in tissue-engineered trachea.
  • To explore factors influencing microvascular network formation within 3D scaffolds.
  • To discuss optimized preparation processes for vascularized tracheal tissues for clinical use.

Main Methods:

  • Literature review of current tissue engineering technologies.
  • Analysis of factors critical for microvascular network development.
  • Exploration of scaffold preparation strategies.

Main Results:

  • Several strategies for tracheal replacement exist, but microvascular network formation in 3D scaffolds requires more attention.
  • Key technologies and influencing factors for microvascularization are identified.
  • Optimized preparation processes are explored for clinical translation.

Conclusions:

  • Microvascular network formation is critical for the success of tissue-engineered trachea.
  • Further research into scaffold design and preparation is needed to enhance vascularization.
  • This review provides insights for developing clinically applicable vascularized tracheal grafts.