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Physical characterization of the hydrates of urapidil
S A Botha1, M R Caira, J K Guillory
1Research Institute for Industrial Pharmacy, University of Potchefstroom for C.H.E., South Africa.
Journal of Pharmaceutical Sciences
|May 1, 1988
Abstract:
Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidil:water). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined.