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Distribution of complete blood count constituents in gestational diabetes mellitus

Yonggang Zhang1, Yipeng Zhang1, Limin Zhao2

  • 1Department of Clinical Laboratory.

Medicine
|June 11, 2021
PubMed

Insights

Gestational diabetes mellitus (GDM) alters blood cell counts during pregnancy. Key differences in neutrophils, lymphocytes, platelets, and red blood cells were observed in GDM patients compared to healthy controls.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Endocrinology

Background:

  • Gestational diabetes mellitus (GDM) affects a significant number of pregnancies.
  • Long-term health risks for both mother and child are associated with GDM.
  • Understanding hematological cell distribution in GDM is crucial for maternal-fetal health.

Purpose of the Study:

  • To investigate the distribution of hematological cells in pregnant women with GDM.
  • To compare hematological parameters between GDM and normal pregnancies over time.

Main Methods:

  • A longitudinal case-control study involving 1860 pregnant women from 2012 to 2018.
  • Hematological parameters were analyzed at 11 gestational time points.
  • Repeated measures analysis and independent t-tests were employed for statistical analysis.

Main Results:

  • Blood cell trends fluctuated with gestational age, more pronounced in GDM.
  • Neutrophils, lymphocytes, and monocytes increased in the second trimester and decreased in the third in GDM.
  • Platelets (PLT), thrombocytocrit, and red blood cells (RBC) showed distinct patterns in GDM pregnancies.

Conclusions:

  • Significant differences in peripheral blood leukocytes, platelets, and erythrocytes exist between GDM and normal pregnancies.
  • These hematological changes suggest potential involvement of inflammatory processes in GDM.
  • Findings highlight distinct hematological profiles associated with GDM during gestation.
Abstract

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