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Published on: March 8, 2012
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Host genetic polymorphisms associated with beta human papillomavirus seropositivity.
Annika Antonsson1,2, Astrid J Rodriguez-Acevedo3, Upekha E Liyanage3
1QIMR Berghofer Medical Research Institute, Brisbane, Australia. Annika.Antonsson@qimrberghofer.edu.au.
Archives of Virology
|June 11, 2021
Summary
This study investigated single nucleotide polymorphisms (SNPs) and their role in the immune response to human papillomaviruses (HPVs). Certain SNPs were found to be associated with seropositivity to beta-HPV types, suggesting a role in the body's defense against these common skin infections.
Area of Science:
- Immunology
- Genetics
- Dermatology
Background:
- Human papillomaviruses (HPVs) establish superficial skin infections.
- Viral clearance depends on eliciting an effective immunological response.
- Cutaneous beta-HPVs are a significant group of HPV types affecting the skin.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) and serological responses to cutaneous beta-human papillomaviruses (HPVs).
- To determine if previously studied SNPs influence the immune system's ability to detect and respond to beta-HPVs.
Main Methods:
- Analysis of serum samples from 1,142 Australian participants.
- Assay for seropositivity against the L1 protein of 21 distinct beta-HPV types.
- Statistical analysis to identify associations between specific SNPs and HPV seropositivity.
Main Results:
- Significant associations were identified between seropositivity to several beta-HPV types and the SNPs rs9264942 (HLA-C), rs12449858 (EVER1), and rs2981451 (FGFR2).
- Specific p-values highlight the statistical significance of these associations for particular HPV types (e.g., HPV-9, HPV-15, HPV-17, HPV-23, HPV-22).
Conclusions:
- Certain single nucleotide polymorphisms (SNPs) are implicated in the serological response to cutaneous beta-HPVs.
- These genetic variations may influence an individual's immune recognition and response to beta-HPV infections.
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