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Related Experiment Video

Updated: Nov 2, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
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Highly Sensitive and Reproducible SERS Substrates Based on Ordered Micropyramid Array and Silver Nanoparticles.

Chengpeng Zhang1,2,3, Shuai Chen1,3, Zhaoliang Jiang1,3

  • 1Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan, Shandong 250061, China.

ACS Applied Materials & Interfaces
|June 11, 2021
PubMed
Summary
This summary is machine-generated.

A novel 3D surface-enhanced Raman scattering (SERS) substrate using micropyramid arrays and silver nanoparticles was developed. This cost-effective substrate demonstrates high sensitivity and stability for detecting molecules like rhodamine 6G and pesticide residues.

Keywords:
FDTD simulationSERSmicropyramid arrayroll-to-plate embossingsilver nanoparticles

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • The practical application of surface-enhanced Raman scattering (SERS) is limited by the development of sensitive and reproducible SERS substrates.
  • Existing SERS substrates often face challenges in terms of cost-effectiveness and scalability for widespread use.

Purpose of the Study:

  • To construct a highly sensitive and reproducible three-dimensional (3D) SERS substrate.
  • To develop an efficient and low-cost fabrication method for SERS substrates.
  • To evaluate the substrate's performance for detecting probe molecules and pesticide residues.

Main Methods:

  • Fabrication of a 3D SERS substrate using ordered micropyramid arrays (MPA) and silver nanoparticles (AgNPs) via roll-to-plate embossing and hydrothermal methods.
  • Performance evaluation using rhodamine 6G (R6G) as a probe molecule to determine sensitivity and enhancement factor.
  • Assessment of substrate stability and repeatability over time.
  • Application in the detection of thiram pesticide residues.

Main Results:

  • Achieved a minimum detection limit of 10-12 M for R6G with an enhancement factor of 8.8 × 109, demonstrating high sensitivity.
  • Exhibited excellent stability and repeatability with a minimum relative standard deviation (RSD) of 4.99% and no significant performance loss after 12 days.
  • Successfully detected thiram pesticide residues down to 1 × 10-7 M, enabling quantitative analysis.

Conclusions:

  • The developed MPA/AgNPs 3D-SERS substrate offers a highly sensitive, reproducible, and stable platform for SERS applications.
  • The efficient and low-cost fabrication process provides a viable route for producing advanced SERS substrates.
  • This research guides the development of practical SERS substrates for sensitive detection in various fields, including food safety.