Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.2K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.2K
Cleavage and Blastulation01:33

Cleavage and Blastulation

48.3K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
48.3K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

3.0K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
3.0K
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

3.7K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
3.7K
Isotonic and Isometric Muscle Contractions01:22

Isotonic and Isometric Muscle Contractions

5.3K
Two primary types of muscle contractions are isotonic and isometric, each serving unique functions and involving distinct mechanisms. Both isotonic and isometric contractions are integral to the body's complex system of movement and stability. Isotonic exercises contribute significantly to functional strength and movement, while isometric contractions are crucial for maintaining posture and joint stability.
Isotonic contractions
Isotonic contractions occur when a muscle changes length while...
5.3K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.9K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A community reconstruction of Chinese hamster metabolism and structural systems biology elucidate metabolic rewiring in lactate-free CHO cells.

Cell systems·2026
Same author

Macrophages restrict tumor immune infiltration by controlling collagen topography.

Science immunology·2026
Same author

Computational Analyses of Bifurcated Inter-Protein Interactions in Protein-Protein Assemblies Reveal Their Pivotal Role in Conferring Stability.

Proteins·2025
Same author

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling.

bioRxiv : the preprint server for biology·2025
Same author

Understanding the Roles of Secondary Shell Hotspots in Protein-Protein Complexes.

Proteins·2025
Same author

Beyond classical domains: The protein unit paradigm - from protein-architecture characterization to downstream applications.

Biochimie·2025
Same journal

circ2DGNN: circRNA-Disease Association Prediction via Transformer-Based Graph Neural Network.

IEEE/ACM transactions on computational biology and bioinformatics·2024
Same journal

Hierarchical Hypergraph Learning in Association- Weighted Heterogeneous Network for miRNA- Disease Association Identification.

IEEE/ACM transactions on computational biology and bioinformatics·2024
Same journal

Discriminative Domain Adaption Network for Simultaneously Removing Batch Effects and Annotating Cell Types in Single-Cell RNA-Seq.

IEEE/ACM transactions on computational biology and bioinformatics·2024
Same journal

MLW-BFECF: A Multi-Weighted Dynamic Cascade Forest Based on Bilinear Feature Extraction for Predicting the Stage of Kidney Renal Clear Cell Carcinoma on Multi-Modal Gene Data.

IEEE/ACM transactions on computational biology and bioinformatics·2024
Same journal

An End-to-End Knowledge Graph Fused Graph Neural Network for Accurate Protein-Protein Interactions Prediction.

IEEE/ACM transactions on computational biology and bioinformatics·2024
Same journal

Generative Biomedical Event Extraction With Constrained Decoding Strategy.

IEEE/ACM transactions on computational biology and bioinformatics·2024
See all related articles

Related Experiment Video

Updated: Nov 2, 2025

Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry
05:45

Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry

Published on: June 8, 2021

3.5K

Shaking the β-Bulges.

Pierrick Craveur, Tarun J Narwani, Narayanaswamy Srinivasan

    IEEE/ACM Transactions on Computational Biology and Bioinformatics
    |June 11, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Beta-bulges, protein structure irregularities, show surprising stability. This study quantifies their dynamics, revealing robust structural behavior with some unexpected exceptions.

    More Related Videos

    Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos
    06:57

    Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

    Published on: July 21, 2021

    2.6K
    Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
    09:09

    Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins

    Published on: August 17, 2022

    2.6K

    Related Experiment Videos

    Last Updated: Nov 2, 2025

    Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry
    05:45

    Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry

    Published on: June 8, 2021

    3.5K
    Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos
    06:57

    Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

    Published on: July 21, 2021

    2.6K
    Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
    09:09

    Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins

    Published on: August 17, 2022

    2.6K

    Area of Science:

    • Protein structure and dynamics
    • Structural bioinformatics
    • Molecular biology

    Background:

    • Beta-bulges are common local irregularities within protein beta-sheets.
    • They occur frequently, comparable to 310 helices.
    • Evolutionary conservation analysis shows beta-bulges are not uniquely conserved.

    Purpose of the Study:

    • To investigate the dynamical behavior of beta-bulges.
    • To quantify the stability of various beta-bulge subtypes using extensive simulation data.
    • To assess the structural robustness of beta-bulges in protein structures.

    Main Methods:

    • Utilized the largest known dataset of protein molecular dynamics simulations.
    • Analyzed the stability of existing beta-bulges during simulations.
    • Categorized and quantified the stability of different beta-bulge subtypes (e.g., AC, AG, PC, AS).

    Main Results:

    • Over 50% of existing beta-bulges remained stable during molecular dynamics simulations.
    • More than 1/6th of beta-bulges were unstable and disappeared.
    • Surprisingly, 1.1% of newly appearing beta-bulges were stable.
    • Common subtypes (AC, AG) showed stability comparable to the overall dataset.
    • Less common, larger subtypes (PC, AS) exhibited significantly higher stability than expected.

    Conclusions:

    • This study provides the first precise quantification of beta-bulge stability.
    • Beta-bulges demonstrate significant structural robustness.
    • Certain less common beta-bulge types display unexpected stability, prompting further structural investigation.